Reduce catastrophic biological risk to zero.
We build careful, agentic research tools that help scientists and policymakers understand emerging biological threats and choose higher-impact defenses.
Query
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| Compound | Target / Property | Affinity |
|---|---|---|
| Osimertinib | EGFR T790M, IC50 9.6nM | -11.2 |
| Rociletinib | EGFR T790M, mutant selective | -10.8 |
| Olmutinib | EGFR T790M, exon 20 ins | -10.4 |
| Lazertinib | EGFR T790M, brain penetrant | -10.1 |
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Drug Discovery
15%
NSCLC 5-year survival, stage IV
2.3M
Deaths globally, 2024
T790M
Resistance mutation in 60% of cases
Four lead compounds were identified with predicted binding affinity below -10.0 kcal/mol against the EGFR T790M gatekeeper mutation. Osimertinib derivative structures showed favourable ADMET profiles with predicted blood-brain barrier permeability, a critical property for central nervous system metastases. The Lazertinib analogue demonstrated the highest CNS penetration score. All four candidates passed the Lipinski filter with zero violations. Next steps involve in vitro kinase assays and cellular viability testing against H1975 cell lines.
Provision ephemeral Neocloud clusters for genomic analysis
01
Select Your Analysis
Choose from genomic sequencing, epidemiological modeling, pathogen identification, or multi-omics analysis. Accelerated Bioresearch supports AWS HealthOmics, EMR, Glue, and custom ML pipelines.
02
Upload Your Data
Drag and drop your datasets onto the portal. Accelerated Bioresearch accepts FASTQ, VCF, BAM, CSV, and Parquet formats. Data is encrypted in transit and at rest using AWS KMS.
03
Launch the Pipeline
AWS Cloud Development Kit templates automatically provision the exact infrastructure your analysis requires. Clusters spin up in under two minutes. You pay only for the compute time you use.
04
Teardown
All provisioned infrastructure is automatically decommissioned upon job completion. Clusters scale to zero within seconds. No idle resources, no surprise billing. Results are archived to S3 for 30 days before permanent deletion.
Analysis Pipelines
Genomic Analysis
AWS HealthOmics powered. Rapid pathogen identification, variant calling, and sequence alignment at scale.
Epidemiological Modeling
Process surveillance data, contact tracing networks, and outbreak simulation using distributed Spark clusters on EMR.
Machine Learning Pipelines
Train, tune, and deploy predictive models on emerging vector data. GPU instances available for deep learning workloads.
Agent Integration
Connect GPT Rosalind and other AI agents directly. Token outputs interface with infrastructure without translation layers.
AutoScientist Architecture
Environment Synthesis
Tool Document
API definitions and tool schemas
Tool Graph
Dependency graph construction
Tool Sequence
Sequence sampling and merging
Synthetic Env
State structure and tool functions
Recursive Self-Intent Refinement
Init Env
Seed environment state
Init Intent
User query parsing
Tool Args
Parameter extraction
Golden Env
Target state definition
Refined Intent
Clarified objective
Reinforcement Learning
Rollout
Agent execution
Tau Matrix
Trajectories
MEU
Maximum expected utility
Reward Fn
Feedback signal
R Matrix
Reward values
Env Comp
State transition
A Matrix
Advantage estimation
Research Archive
Superhuman Game AI Disclosure: Expertise and Context Moderate Effects on Trust and Fairness
First author. A human-factors study on how disclosure of superhuman AI capability affects player trust in video game environments.
View on arXiv
Guardrail Guided Policy Optimisation: Learning Disentangled Safety Constraints
First author. A guardrail mechanism that prevents unsafe policy optimisation in reinforcement learning agents.
View on Springer
Streaming 4K/UHD Video to the Rest of Us: Can Bandwidth Sharing Help?
Major contributor. Kernel implementation for a novel multi-path networking algorithm. Led to a role at Amazon Web Services.
View on IEEE
Partners
AWS Imagine Grant
Endymion applied for the AWS Imagine Grant, a philanthropic initiative funding cloud-native solutions for 501(c)(3) nonprofits, to support the platform's backend expansion.
Research Network
Vafaee Biomedical AI Laboratory
A biomedical AI research group advancing disease diagnostics, drug discovery, and single-cell multi-omics analysis. Develops open-source tools and analytical pipelines with a commitment to precision, reproducibility, and interpretability in computational medicine.
The University of New South Wales
Operates the UNSW Health Translation Hub within the Randwick Health & Innovation Precinct, alongside the Kolling Institute and the School of Biotechnology and Biomolecular Sciences. Covers cancer, personalised medicine, advanced therapeutics, dementia and ageing, and machine learning for biomedicine.
The University of Sydney
Hosts the Sydney Infectious Diseases Institute, a flagship centre for infectious diseases research. Covers pathogen evolution, antimicrobial resistance, vaccine development, epidemiology, and public health response frameworks across tuberculosis, HIV, and emerging pathogens.
CSIRO
Australia's national science agency. Operates the Australian Centre for Disease Preparedness, a BSL-4 facility in Geelong dedicated to exotic animal disease diagnosis, zoonotic pathogen research, vaccine development, and biosecurity preparedness.
Garvan Institute of Medical Research
World-leading genomic research institute specialising in cellular genomics, single-cell sequencing, and spatial transcriptomics. The Kinghorn Centre for Clinical Genomics powers large-scale genome sequencing for rare disease diagnosis and cancer research.
Events
Endymion Events
Workshops, demonstrations, and community sessions. Past and upcoming events.
View Calendar